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Dignam, James J.

One or more keywords matched the following properties of Dignam, James J.

Property	Value
keywords	health disparities in cancer
overview	Dr. Dignam's primary research involves the design, conduct, and analysis of cancer clinical trials, including early development (phase I), pilot efficacy and safety (phase II), and definitive evaluation (phase III) trials. He is the Executive Director of the Statistics and Data Management Center for NRG Oncology, a National Cancer Institute sponsored multi-center clinical trials group with over 500 recruitment sites in North America and beyond and over 100 active clinical trials. Dr. Dignam's methodology interests include trial monitoring and early stopping rules, competing risks, hazard function estimation, and prognostic modeling. He also has engaged in and led investigations into sociodemographic factors such as race/ethnicity and BMI/obesity on cancer prognosis and treatment response. Courses taught include introductory biostatistics, clinical trials, survival analysis, and regression modeling methods.

Property

Value

keywords

health disparities in cancer

overview

Dr. Dignam's primary research involves the design, conduct, and analysis of cancer clinical trials, including early development (phase I), pilot efficacy and safety (phase II), and definitive evaluation (phase III) trials. He is the Executive Director of the Statistics and Data Management Center for NRG Oncology, a National Cancer Institute sponsored multi-center clinical trials group with over 500 recruitment sites in North America and beyond and over 100 active clinical trials. Dr. Dignam's methodology interests include trial monitoring and early stopping rules, competing risks, hazard function estimation, and prognostic modeling. He also has engaged in and led investigations into sociodemographic factors such as race/ethnicity and BMI/obesity on cancer prognosis and treatment response. Courses taught include introductory biostatistics, clinical trials, survival analysis, and regression modeling methods.

One or more keywords matched the following items that are connected to Dignam, James J.

Item Type	Name
Concept	Breast Neoplasms
Concept	Attitude of Health Personnel
Concept	Cancer Care Facilities
Concept	Colonic Neoplasms
Concept	Health Surveys
Concept	Colorectal Neoplasms, Hereditary Nonpolyposis
Concept	Liver Neoplasms
Concept	Health Services Accessibility
Concept	Oropharyngeal Neoplasms
Concept	Pancreatic Neoplasms
Concept	Ovarian Neoplasms
Concept	Lung Neoplasms
Concept	Prostatic Neoplasms
Concept	Pleural Neoplasms
Concept	Rectal Neoplasms
Concept	Head and Neck Neoplasms
Concept	Health Knowledge, Attitudes, Practice
Concept	Neoplasms, Second Primary
Concept	Endometrial Neoplasms
Concept	National Institutes of Health (U.S.)
Concept	Neoplasms, Experimental
Concept	Quality Assurance, Health Care
Concept	Quality of Health Care
Concept	National Cancer Institute (U.S.)
Concept	Health Status Disparities
Concept	Skin Neoplasms
Concept	Colorectal Neoplasms
Concept	Electronic Health Records
Concept	Early Detection of Cancer
Concept	Healthcare Disparities
Concept	Health Literacy
Concept	Brain Neoplasms
Concept	Neoplasms
Academic Article	Sequential methotrexate and fluorouracil for the treatment of node-negative breast cancer patients with estrogen receptor-negative tumors: eight-year results from National Surgical Adjuvant Breast and Bowel Project (NSABP) B-13 and first report of findings from NSABP B-19 comparing methotrexate and fluorouracil with conventional cyclophosphamide, methotrexate, and fluorouracil.
Academic Article	Tamoxifen and chemotherapy for lymph node-negative, estrogen receptor-positive breast cancer.
Academic Article	Prognosis among African-American women and white women with lymph node negative breast carcinoma: findings from two randomized clinical trials of the National Surgical Adjuvant Breast and Bowel Project (NSABP).
Academic Article	Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors.
Academic Article	Coronary heart disease mortality and adjuvant tamoxifen therapy.
Academic Article	Breast cancer trials on trial: a case of conflicting ethical interests.
Academic Article	Early stopping of a clinical trial when there is evidence of no treatment benefit: protocol B-14 of the National Surgical Adjuvant Breast and Bowel Project.
Academic Article	Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial.
Academic Article	Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) eight-year update of Protocol B-17: intraductal carcinoma.
Academic Article	Prognosis and treatment of patients with breast tumors of one centimeter or less and negative axillary lymph nodes.
Academic Article	Occurrence of stroke with tamoxifen in NSABP B-24.
Academic Article	Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the National Surgical Adjuvant Breast and Bowel Project experience.
Academic Article	Outcomes among African-Americans and Caucasians in colon cancer adjuvant therapy trials: findings from the National Surgical Adjuvant Breast and Bowel Project.
Academic Article	Findings from recent National Surgical Adjuvant Breast and Bowel Project adjuvant studies in stage I breast cancer.
Academic Article	Differences in breast cancer prognosis among African-American and Caucasian women.
Academic Article	Efficacy of systemic adjuvant therapy for breast cancer in African-American and Caucasian women.
Academic Article	Five versus more than five years of tamoxifen for lymph node-negative breast cancer: updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial.
Academic Article	MYC is amplified in BRCA1-associated breast cancers.
Academic Article	The role of cancer cooperative groups within the spectrum of cancer care.
Academic Article	Benefits and costs of interventions to improve breast cancer outcomes in African American women.
Academic Article	Is patient travel distance associated with survival on phase II clinical trials in oncology?
Academic Article	Semiquantitative analysis of dynamic contrast enhanced MRI in cancer patients: Variability and changes in tumor tissue over time.
Academic Article	Statistical considerations in assessing molecular markers for cancer prognosis and treatment efficacy.
Academic Article	Mammographic density and breast cancer after ductal carcinoma in situ.
Academic Article	Toward optimal screening strategies for older women. Costs, benefits, and harms of breast cancer screening by age, biology, and health status.
Academic Article	Obesity, tamoxifen use, and outcomes in women with estrogen receptor-positive early-stage breast cancer.
Academic Article	Colorectal cancer and race: understanding the differences in outcomes between African Americans and whites.
Academic Article	How often do BRCA mutation carriers tell their young children of the family's risk for cancer? A study of parental disclosure of BRCA mutations to minors and young adults.
Academic Article	BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy.
Academic Article	Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer.
Academic Article	Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer.
Academic Article	Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18.
Academic Article	The ongoing search for the sources of the breast cancer survival disparity.
Academic Article	Comments on: Yin W, Di G, Zhou L, Lu J, Liu G, Wu J, Shen K, Han Q, Shen Z, Shao Z. Time-varying pattern of recurrence risk for Chinese breast cancer patients.
Academic Article	Treatment of lymph-node-negative, oestrogen-receptor-positive breast cancer: long-term findings from National Surgical Adjuvant Breast and Bowel Project randomised clinical trials.
Academic Article	Early viewing of noninferiority trials in progress.
Academic Article	Family history of pancreatic cancer in a high-risk cancer clinic: implications for risk assessment.
Academic Article	Hazard of recurrence and adjuvant treatment effects over time in lymph node-negative breast cancer.
Academic Article	Re: Racial disparities in cancer survival among randomized clinical trials of the Southwest Oncology Group.
Academic Article	A missing data approach to semi-competing risks problems.
Academic Article	Epidermal growth factor receptor inhibitor gefitinib added to chemoradiotherapy in locally advanced head and neck cancer.
Academic Article	A pilot study of the vulnerable elders survey-13 compared with the comprehensive geriatric assessment for identifying disability in older patients with prostate cancer who receive androgen ablation.
Academic Article	Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS.
Academic Article	Estrogen receptor alpha, BRCA1, and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers.
Academic Article	Uptake and timing of bilateral prophylactic salpingo-oophorectomy among BRCA1 and BRCA2 mutation carriers.
Academic Article	Population differences in breast cancer: survey in indigenous African women reveals over-representation of triple-negative breast cancer.
Academic Article	Multiple imputation methods for inference on cumulative incidence with missing cause of failure.
Academic Article	p53 as a marker of prognosis in African-American women with breast cancer.
Academic Article	Conditional survival and the choice of conditioning set for patients with colon cancer: an analysis of NSABP trials C-03 through C-07.
Academic Article	Outcomes among black patients with stage II and III colon cancer receiving chemotherapy: an analysis of ACCENT adjuvant trials.
Academic Article	Predictors of competing mortality in advanced head and neck cancer.
Academic Article	Colorectal cancer model of health disparities: understanding mortality differences in minority populations.
Academic Article	The use and interpretation of competing risks regression models.
Academic Article	Diffusing capacity predicts long-term survival after lung resection for cancer.
Academic Article	Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline.
Academic Article	Optimization of response classification criteria for patients with malignant pleural mesothelioma.
Academic Article	Predictors of locoregional recurrence after neoadjuvant chemotherapy: results from combined analysis of National Surgical Adjuvant Breast and Bowel Project B-18 and B-27.
Academic Article	Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in patients treated by breast-conserving therapy in five National Surgical Adjuvant Breast and Bowel Project protocols of node-negative breast cancer.
Academic Article	Estimating breast cancer-specific and other-cause mortality in clinical trial and population-based cancer registry cohorts.
Academic Article	Some additional thoughts on time-varying treatment effects in breast cancer.
Academic Article	Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17.
Academic Article	Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less.
Academic Article	Prognosis after rectal cancer in blacks and whites participating in adjuvant therapy randomized trials.
Academic Article	Semiparametric models for cumulative incidence functions.
Academic Article	Obesity and breast cancer prognosis: an expanding body of evidence.
Academic Article	Choice and interpretation of statistical tests used when competing risks are present.
Academic Article	Population-based survival-cure analysis of ER-negative breast cancer.
Academic Article	Glioma-associated oncogene family zinc finger 1 expression and metastasis in patients with head and neck squamous cell carcinoma treated with radiation therapy (RTOG 9003).
Academic Article	Race and the prognostic influence of p53 in women with breast cancer.
Academic Article	Redesigning radiotherapy quality assurance: opportunities to develop an efficient, evidence-based system to support clinical trials--report of the National Cancer Institute Work Group on Radiotherapy Quality Assurance.
Academic Article	Patterns of missing mini mental status exam (MMSE) in radiation therapy oncology group (RTOG) brain cancer trials.
Academic Article	NCI-RTOG translational program strategic guidelines for the early-stage development of radiosensitizers.
Academic Article	Disease volumes as a marker for patient response in malignant pleural mesothelioma.
Academic Article	Integrated phase II/III clinical trials in oncology: a case study.
Academic Article	Baseline comorbidities in a skin cancer prevention trial in Bangladesh.
Academic Article	A nomogram for individualized estimation of survival among patients with brain metastasis.
Academic Article	Lung volume measurements as a surrogate marker for patient response in malignant pleural mesothelioma.
Academic Article	Multiple imputation methods for nonparametric inference on cumulative incidence with missing cause of failure.
Academic Article	A randomized trial of bevacizumab for newly diagnosed glioblastoma.
Academic Article	Bayesian Hierarchical Multiresolution Hazard Model for the Study of Time-Dependent Failure Patterns in Early Stage Breast Cancer.
Academic Article	Bayesian approach for flexible modeling of semicompeting risks data.
Academic Article	Hormone replacement therapy and breast cancer: heterogeneous risks by race, weight, and breast density.
Academic Article	Assessing treatment benefit with competing risks not affected by the randomized treatment.
Academic Article	Individualized dynamic prediction of prostate cancer recurrence with and without the initiation of a second treatment: Development and validation.
Academic Article	A tissue biomarker-based model that identifies patients with a high risk of distant metastasis and differential survival by length of androgen deprivation therapy in RTOG protocol 92-02.
Academic Article	Duration of androgen suppression before radiotherapy for localized prostate cancer: radiation therapy oncology group randomized clinical trial 9910.
Academic Article	Building firm foundations for therapy development.
Academic Article	Reply to M.C. Chamberlain.
Academic Article	Prevention of colorectal cancer and dietary management.
Academic Article	Variation over time and interdependence between disease progression and death among patients with glioblastoma on RTOG 0525.
Academic Article	Randomized Phase III Noninferiority Study Comparing Two Radiotherapy Fractionation Schedules in Patients With Low-Risk Prostate Cancer.
Academic Article	Joint modelling of longitudinal and multi-state processes: application to clinical progressions in prostate cancer.
Academic Article	Comparison of futility monitoring guidelines using completed phase III oncology trials.
Academic Article	Promoting the Appropriate Use of Advanced Radiation Technologies in Oncology: Summary of a National Cancer Policy Forum Workshop.
Academic Article	Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer.
Academic Article	A Multiresolution Hazard Model for Multicenter Survival Studies: Application to Tamoxifen Treatment in Early Stage Breast Cancer.
Academic Article	An Evaluation of Psychosocial and Religious Belief Differences in a Diverse Racial and Socioeconomic Urban Cancer Population.
Academic Article	Flexible modeling of the hazard rate and treatment effects in long-term survival studies.
Academic Article	Effect of body mass index on outcomes in patients with Dukes B and C colon cancer: An analysis of NSABP randomized trials.
Academic Article	Duration of Androgen Deprivation in Locally Advanced Prostate Cancer: Long-Term Update of NRG Oncology RTOG 9202.
Academic Article	Universal screening for Lynch syndrome in a large consecutive cohort of Chinese colorectal cancer patients: High prevalence and unique molecular features.
Academic Article	Metastasis-Free Survival Is a Strong Surrogate of Overall Survival in Localized Prostate Cancer.
Academic Article	Investigating the Effect of Reirradiation or Systemic Therapy in Patients With Glioblastoma After Tumor Progression: A Secondary Analysis of NRG Oncology/Radiation Therapy Oncology Group Trial 0525.
Academic Article	Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial.
Academic Article	Efficacy of Anti-HER2 Agents in Combination With Adjuvant or Neoadjuvant Chemotherapy for Early and Locally Advanced HER2-Positive Breast Cancer Patients: A Network Meta-Analysis.
Academic Article	Time Interval to Biochemical Failure as a Surrogate End Point in Locally Advanced Prostate Cancer: Analysis of Randomized Trial NRG/RTOG 9202.
Academic Article	Smoking, age, nodal disease, T stage, p16 status, and risk of distant metastases in patients with squamous cell cancer of the oropharynx.
Academic Article	Quality of Life in Patients With Low-Risk Prostate Cancer Treated With Hypofractionated vs Conventional Radiotherapy: A Phase 3 Randomized Clinical Trial.
Academic Article	Association of Black Race With Prostate Cancer-Specific and Other-Cause Mortality.
Academic Article	A Systematic Review and Recommendation for Reporting of Surrogate Endpoint Evaluation Using Meta-analyses.
Award or Honor Receipt	Inducted Member
Academic Article	Association of Presalvage Radiotherapy PSA Levels After Prostatectomy With Outcomes of Long-term Antiandrogen Therapy in Men With Prostate Cancer.
Academic Article	Event-Free Survival, a Prostate-Specific Antigen-Based Composite End Point, Is Not a Surrogate for Overall Survival in Men With Localized Prostate Cancer Treated With Radiation.
Academic Article	Characteristics of Participation in Patient-Reported Outcomes and Electronic Data Capture Components of NRG Oncology Clinical Trials.
Academic Article	Multicenter Clinical Cancer Research After COVID-19: A Perspective From NRG Oncology.
Academic Article	Disparities in Breast Cancer: Narrowing the Gap.
Academic Article	Validation of a 22-Gene Genomic Classifier in Patients With Recurrent Prostate Cancer: An Ancillary Study of the NRG/RTOG 9601 Randomized Clinical Trial.
Academic Article	Appropriate Systemic Therapy Dosing for Obese Adult Patients With Cancer: ASCO Guideline Update.
Academic Article	Hematuria following Post-Prostatectomy Radiotherapy: Incidence Increases with Long-Term Followup.
Academic Article	Predictors of Pneumonitis in Combined Thoracic Stereotactic Body Radiation Therapy and Immunotherapy.
Academic Article	Early Endpoints in High-risk Localized Prostate Cancer: Exploratory Analysis of Three Radiation Therapy Oncology Group Phase 3 Studies.
Academic Article	Cardiovascular Mortality and Duration of Androgen Deprivation in Locally Advanced Prostate Cancer: Long-term Update of NRG/RTOG 9202.

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health
disparities
cancer